Selective and quantitative functionalization of unprotected α-amino acids using a recyclable homogeneous catalyst

A new Ir(III)-NHC catalyst is reported that shows remarkable activity in the N-alkylation of unprotected amino acids. The catalytic system gives excellent selectivity toward monoalkylated α-amino acids and a high degree retention stereochemistry. wide range nonnatural have been prepared. These compounds represent an array building blocks could be used for direct synthesis peptidomimetics. amino-acid-based surfactants also reported. This method acid products quantitative yield; hence, tedious purifications by derivatization are therefore avoided. Furthermore, although homogeneous metal complex, it can recycled reused several runs. contributes to efficiency sustainability method.